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DBCO-PEG4-amine,1840886-10-3,二苯基环辛炔-四聚乙二醇-胺的介绍

2023-06-01 [152]

产品名称:

DBCO-PEG4-amine,1840886-10-3,二苯基环辛炔-四聚乙二醇-胺

中文名称:二苯基环辛炔-四聚乙二醇-

别称:二苯并环辛炔-四聚乙二醇-

英文名称:DBCO-PEG4-amine

别称:DBCO-PEG2-amine TFA salt;DBCO-PEG4-amine TFA salt;Dibenz[b,f]azocine-5(6H)-but*, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-

产品详情:

分子式:C29H37N3O6

分子量:523.63

CAS1840886-10-3

沸点:784.1±60.0°C(Predicted)

密度:1.23±0.1g/cm3(Predicted)

溶解度:SolubleinDMSO,DCM,DMF

酸度系数:(pKa)15.14±0.46(Predicted)

储存:-20℃ 一年

【结构式】

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产品描述:

生物活性:DBCO-PEG4-amine是一种PROTAC连接桥,属于PEG类。DBCO-PEG4-amine可用于合成一系列PROTAC分子。DBCO-PEG4-amine是一种可降解(cleavable)ADC连接桥,用于抗体药物结合物(ADCs)的合成。DBCO-PEG4-amine可用来合成一种同双功能叠氮化物至叠氮化物交联剂FPM-PEG4-DBCO

靶点CleavablePEGs

体外研究PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

DBCO (二苯并环辛炔) 氨基衍生物,可与含有羧基的生化小分子形成稳定酰胺键连接。

关于我们:

陕西星贝爱科生物科技经营的产品种类包括有:合成磷脂、高分子聚乙二醇衍生物、嵌段共聚物、磁性纳米颗粒、纳米金及纳米金棒、近红外荧光染料、活性荧光染料、荧光标记物、蛋白交联剂、小分子PEG衍生物、点击化学产品、树枝状聚合物、环糊精衍生物、大环配体类、荧光量子点、透明质酸衍生物、石墨烯或氧化石墨烯、碳纳米管、富勒烯,二氧化硅及介孔二氧化硅,聚合物微球,近红外荧光染料,聚苯乙烯微球,上转换纳米发光颗粒,MRI核磁造影产品,荧光蛋白及荧光探针等等。

温馨提示:供应产品仅用于科研,不能用于人体!

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